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Needleman–Wunsch algorithm
The Needleman–Wunsch algorithm is an algorithm used in bioinformatics to align protein or nucleotide sequences. It was one of the first applications of dynamic programming to compare biological sequences. The algorithm was developed by Saul B. Needleman and Christian D. Wunsch and published in 1970. The algorithm essentially divides a large problem (e.g. the full sequence) into a series of smaller problems and uses the solutions to the smaller problems to reconstruct a solution to the larger problem.〔(【引用サイトリンク】website=http://www.britannica.com/EBchecked/topic/1334661/bioinformatics/285871/Goals-of-bioinformatics#ref1115380 )〕 It is also sometimes referred to as the optimal matching algorithm and the global alignment technique. The Needleman–Wunsch algorithm is still widely used for optimal global alignment, particularly when the quality of the global alignment is of the utmost importance.
==Beginner's How-To Guide==
This algorithm can be used for any two strings. This guide will use two small DNA sequences as examples as shown in the diagram:
GCATGCU
GATTACA
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